Neurobiological advances identify novel antidepressant targets

Cytogenetic and Neurobiological Advances in Down syndrome

Título: Avances Citogenéticos y Neurobiológicos en el Síndrome de Down. Resumen: El síndrome de Down es una alteración autosómica que, tradicionalmente, ha sido estudiada de forma independiente, desde ámbitos como la medicina, la biología o la psicología. En este artículo pretendemos ir más allá e incorporar una perspectiva multidisciplinar que contemple, por una parte, los principales hallazgo...

A Riboproteomic Platform to Identify Novel Targets for Prostate Cancer Therapy A Riboproteomic Platform to Identify Novel Targets for Prostate Cancer Therapy”

Novel neurobiological roles of UBE3A

The mechanistic target of rapamycin (mTOR) is a highly conserved and ubiquitously expressed kinase, which consists of two distinct protein complexes, referred to as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1, coupled to Raptor, and mTORC2, coupled to Rictor, respond to different signals and target different substrates; while mTORC1 is activated by a number of signals, including...

Imidazoline binding sites on receptors and enzymes: emerging targets for novel antidepressant drugs?

Clonidine, like many other imidazoline drugs, is usually thought of as a selective α2-adrenergic agonist and is approved for use as a centrally acting antihypertensive agent. In addition, clonidine is prescribed off-label to treat some cases of Tourette’s syndrome, and it may also have a role in the treatment of other psychiatric conditions, including obsessive–compulsive disorders, panic state...

Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies.

Lithium used as a drug treatment for major mental disorders such as bipolar disorder and depression is effective in reducing the risk of both attempted and completed suicide. However, the mechanisms underlying lithium's antisuicidal actions are not yet known, limiting the development of novel lithium-mimetic compounds that may help reduce suicide risk with fewer undesirable side effects. Suicid...